【摘要】 目的:了解银杏达莫注射液不良反应(ADR)发生的特点和一般规律,为临床合理用药提供参考。方法:以"银杏达莫注射液""不良反应"为主题词,检索中国学术期刊全文数据库2005年1月1日-2016年6月28日收载的期刊文献,对患者性别、年龄、原患疾病、过敏史、用药情况、ADR发生时间、累及器官/系统及临床表现等进行统计、分析。结果:检索得到有效文献14篇,共计727例患者。其中,女性多于男性(57.63%vs.42.37%),年龄多在50岁以上,原患疾病以血栓栓塞性疾病、冠心病为主;ADR多在用药30 min内发生(268例,36.86%);累及器官/系统以神经系统(254例,28.60%)、皮肤及其附件(228例,25.68%)和消化系统(187例,21.06%)为主,严重者可致过敏性休克;新的严重的ADR 18例(2.48%);所有ADR均好转,无死亡病例。结论:临床应严格掌握银杏达莫注射液的适应证,辨证施治、合理用药,对用药过程严密观察,警惕ADR的发生。更多还原

【Abstract】 OBJECTIVE:To investigate the characteristics and general rule of ADR induced by Ginkgo leaf extract and dipyridamole injection,and to provide reference for clinical rational drug use. METHODS:Using"Ginkgo leaf extract and dipyridamole injection""ADR"as subject,the journal articles were retrieved from CJFD during Jan. 1st,2005-Jun. 28 th,2016,and then analyzed statistically in respects of gender,age,primary disease,allergic disease,drug use,occurrence time of ADR,organs/systems involved and clinical manifestations. RESULTS:A total of 14 valid articles had been collected,involving 727 patients in total.Meanwhile,female was more than male(57.63% vs. 42.37%)and most of them aged more than 50 years;primary diseases were mainly thromboembolic disease and coronary heart disease;most of ADR happened within 30 min after medication(268 cases,36.86%). Organs/systems involved in ADR were mainly nervous system(254 cases,28.60%),followed by skin and its appendants(228 cases,25.68%),digestive system(187 cases,21.06%);severe ADR could cause anaphylactic shock. There were 18 cases of new severe ADR(2.48%);all ADR cases were recovered,and no death occurred. CONCLUSIONS:It is suggested to strictly control indications,differential diagnosis and treatment,rational drug use,close monitoring through the whole process,maintain a high level of awareness to ADR.更多还原