【摘要】 目的:考察小酸枣汤对小鼠自主活动及睡眠时间的影响,并进行拆方研究。方法:将小酸枣汤组方中7味药材（酸枣仁、茯苓、川芎、知母、甘草、生姜、桂心）作为实验因素,每个因素选取有或无2个水平,按L₈（2⁷）正交表安排试验。采用直观分析法和方差分析法比较小酸枣汤组方和方中各单味药对小鼠2 min内自主活动及阈上剂量戊巴比妥钠致小鼠睡眠时间的影响。结果:小酸枣汤组方中对小鼠自主活动具有明显影响作用的是酸枣仁和知母;对阈上剂量戊巴比妥钠所致小鼠睡眠时间有明显影响的是酸枣仁。结论:小酸枣汤具有抑制小鼠自主活动及延长阈上剂量戊巴比妥钠致小鼠睡眠时间的作用,方中酸枣仁作用最强。更多还原

【Abstract】 OBJECTIVE:To investigate the effects of Xiaosuanzao decoction on spontaneous motion and sleep time in mice,and to study its disassembled formulation. METHODS:Seven ingredients of Xiaosuanzao decoction were selected as the influential factors,including Ziziphus jujuba,Poria cocos,Ligusticum chuanxiong,Anemarrhena asphodeloides,Glycyrrhiza uralensis,Zingiber officinale and Cortex cinnamoni. Two levels of with or without were designed for each factor,and the experiment was arranged according to L₈（2⁷）orthogonal test table. The effects of Xiaosuanzao decoction and each ingredient on spontaneous motion within 2 min and sleep time induced by superthreshold dosage of pentobarbital sodium were compared by visual analysis method and analysis of variance. RESULTS:Z. jujube and A. asphodeloides were the main active ingredients of Xiaosuanzao decoction on spontaneous motion;Z. jujube was the main active ingredient of Xiaosuanzao decoction on sleep time induced by superthreshold dosage of pentobarbital sodium. CONCLUSIONS:Xiaosuanzao decoction can inhibit spontaneous motion and prolong sleep time induced by superthreshold dosage of pentobarbital sodium,and Z. jujube is the main ingredient of Xiaosuanzao decoction.更多还原