【摘要】 定植于宿主肠道中的微生物参与了宿主多种生理功能以及相关疾病的发生。一个新的医学研究热点在近年内逐渐被关注,肠道菌群可通过主要由神经—内分泌介导的肠—脑轴(gut-brain axis,GBA)与大脑进行双向式交流。GBA不仅实现了肠道菌群对大脑发育和功能的影响,也促使大脑对肠道菌群结构和多样性的改变成为可能。本文旨在对肠道菌群与大脑相互作用的研究进展作一综述,以期为肠道和大脑功能领域的研究以及重要相关疾病的治疗策略提供理论依据。更多还原

【Abstract】 Gut microbiota inhabiting in the host plays an important role in a variety of physiological functions and related diseases.In recent years,the gut-brain axis(GBA)has been found to be a nerve-endocrine mediated bidirectional communication system between gut microbiota and brain,which as a novel medical research highlight has received widespread attention from researchers.GBA not only affects the development and function of brain via gut microbiota,but also makes it possible for brain to change the structure and diversity of gut microbiota.This article reviews the interaction between gut microbiota and brain via GBA,with the intention of providing a reference for further researches on the functions of intestinal tract and brain,as well as the therapeutic strategies of related diseases.更多还原