【摘要】 长链非编码RNA(lncRNA)作为一类长度超过200个核苷酸的功能性RNA与许多内分泌和代谢疾病密切相关。研究表明,lncRNA可在多水平调控基因表达,包括参与染色质印记,与表观修饰复合物或转录因子结合发挥转录水平的调控,与miRNA、mRNA或蛋白质结合发挥转录后水平的调控等。lncRNA表达的失调及一级序列的突变或二级结构的改变与许多人类疾病相关,而在糖尿病肾脏疾病(DKD)方面的研究还处于起步阶段。此外,由于部分lncRNA可以在人体液中检测到并且具有良好的特异性和可及性,因此,推测lncRNA可作为DKD诊断和预后的新型潜在生物标记物。更多还原

【Abstract】 Objective Long non-coding RNA(lncRNA),with more than 200 nucleotides in length,is closely related to many endocrine and metabolic diseases as a functional RNA.Researches has shown that lncRNA can regulate gene expression in multiple levels,including participation in chromatin imprints,in combination with apparent modified complexes or transcription factors to play a transcriptional regulation,and binding with miRNA,mRNA or protein to play the role of post-transcriptional regulation.The disorder of lncRNA expression and the mutation of the primary sequence or variation of the secondary structure are associated with many human diseases.The study of lncRNA in diabetic kidney disease is still in its infancy.In addition,since some lncRNA can be detected in human body fluid and have good specificity and accessibility,it is speculated that lncRNA can be used as a new potential biomarker for the diagnosis and prognosis of diabetic kidney disease.更多还原