【摘要】 菌群与宿主相互关系等热点研究促进了对无菌动物需求的迅猛发展。无菌猪作为一种特殊的模式动物,其在科学研究中不仅排除了背景微生物因素的影响,而且与常用的无菌小鼠相比,其在解剖、生理、代谢等方面与人更为相似,因此在生命科学研究领域具有重要的应用价值。本文结合现有国外无菌猪研究进展和本实验室在无菌猪研究积累,就无菌猪的制备与微生物质量控制进行简要探讨。更多还原

【Abstract】 The industry of germ-free animals has been a hot spot in research along with the rapid development of studies on the relationship between microbiota and host diseases. Because it is pathogen-free,and the high degree of similarity in anatomy,physiology,pathogenesis to humans,germ-free pig is considered a clinical relevant model to be widely used in life science research. Based on the current state of research of germ-free pig cultivation at home and abroad and the experimental studies carried out in our laboratory as well,this article gives a simple discussion on germ-free technique of domestic pigs.更多还原