【摘要】 抑郁症是一种基因与环境交互影响的重大精神疾病。其发病机制学说众多,但仍未获得广泛认同。肠道微生物是人体最大、最直接的外环境,已成为解析抑郁症的全新切入点。根据最新研究进展,本文将从以下几个方面来进行综述:(1)肠道微生物通过"微生物-肠-脑"轴影响脑神经生化和行为表型;(2)肠道微生物紊乱与抑郁发生的相关性;(3)肠道微生物在抑郁发生中的潜在致病机制;(4)展望以抑郁症肠道微生物紊乱为靶点,开发抑郁症新的诊治方法。更多还原

【Abstract】 Major depressive disorder( MDD) is one of the severe mental illness caused by genetic and environmental interactions. There are several hypotheses that sought to account for this disorder. However,none of them is widely recognized. Gut microbiome,the largest and most direct external environment for human body,is considered as a new focus in the research of MDD. Based on the new development,we will summarize the following aspects of MDD in this article:( 1) How the gut microbiome shapes the brain neurochemistry and behaviors through microbiota-gut-brain axis?( 2) Association between disturbances of gut microbiome and MDD;( 3) The potential pathogenesis of gut microbiome in the onset of MDD;( 4) The prospects of developing new diagnosis and treatment for MDD by targeting microbiota-gut-brain axis.更多还原