【摘要】 目的探讨血管内栓塞治疗颅内破裂动脉瘤的近期疗效及对患者免疫功能的影响。方法 2011年6月至2015年6月收治颅内破裂动脉瘤52例,根据治疗方法分为观察组和对照组,各26例。观察组采用血管内栓塞治疗,其中球囊辅助弹簧圈栓塞14例,单纯弹簧圈栓塞12例;对照组采用开颅夹闭术治疗。术后6个月采用GOS评分评估预后。术前、术后1、3 d采用免疫比浊法检测外周血IgG、IgM、IgA等免疫功能指标。结果术后6个月,观察组GOS评分5分17例,4分5例,3分3例,2分1例,1分0例;对照组分别为9、8、6、2、1例;观察组预后明显优于对照组(P<0.05)。对照组术后1、3 d外周血IgA、IgG、IgM等水平较术前均明显降低(P<0.05)。观察组术后1 d外周血IgA、IgG、IgM等水平较术前均明显降低(P<0.05),但是术后3 d各免疫功能指标水平恢复到术前水平(P>0.05)。观察组术后1、3 d外周血IgA、IgG、IgM等水平均明显高于对照组(P<0.05)。结论颅内破裂动脉瘤采用血管内栓塞治疗近期疗效显著,对围术期免疫功能影响较小,且术后并发症发生率较低。更多还原

【Abstract】 Objective To explore the short-term curative effect of endovascular embolization on ruptured intracranial aneurysms and its influence on immune function.Methods Fifty-two patients with ruptured intracranial aneurysms were divided into two groups,observation group in which 26 patients received endovascular embolization,and control group in which 26 received craniotomy for the ruptured intracranial aneurysms.The recent curative effect and the immune function were compared between the two groups.Results The rate of good curative effect(65.38%,17/26) was significantly higher in the observation group than that(34.61%,10/26) in the control group 6 months after the treatment(P<0.05).The incidence of complications was significantly lower in the observation group(15.38%)than that(46.15%) in the control group(P<0.05).The plasma levels of IgA,IgG and IgM were significantly higher in the observation group than those in the control group 1 and 3 days after the treatment(P<0.05).Conclusions The recent curative effect of endovascular embolization on ruptured intracranial aneurysms is significantly better than that of the craniotomy and it produces fewer complications and less influence on the immune function compared to the craniotomy in the patients with ruptured intracranial aneurysms.更多还原