【摘要】 目的比较分析河北省脊髓灰质炎(脊灰)疫苗预防接种的安全性。方法收集河北省2015年5-10月三价脊灰减毒活疫苗(tOPV)、脊灰灭活疫苗(IPV)和2016年同期二价脊灰减毒活疫苗(bOPV)、IPV的疑似预防接种异常反应(AEFI)监测数据,比较分析各疫苗AEFI报告发生率。结果河北省2015年5-10月tOPV、IPV的AEFI报告发生率分别为5.64/10万、35.96/10万;2016年同期bOPV、IPV的AEFI报告发生率分别为16.06/10万、17.85/10万。各疫苗AEFI均以≤1岁年龄组、一般反应为主,主要发生在接种疫苗后≤48h。结论河北省各脊灰疫苗预防接种安全性良好,bOPV的AEFI报告发生率高于tOPV,需进一步加强脊灰疫苗安全性监测。更多还原

【Abstract】 Objective To analyze the safety profile of polio vaccines used in Hebei province. Methods We collected adverse events following immunization( AEFI) data on trivalent oral polio attenuated live vaccine( tOPV) and inactivated polio vaccine( IPV) from May to October in 2015,and AEFI data on bivalent oral polio attenuated live vaccine( bOPV) and IPV from May to October in 2016 through the AEFI Information Management System and compared AEFI incidence rates. Results AEFI incidence rates of tOPV and IPV from May to October in 2015 were 5. 64 and 35. 96 reported events per 100 000 doses,respectively.AEFI incidence rates of bOPV and IPV from May to October in 2016 were 16. 06 and 17. 85 per 100 000 doses,respectively. Most AEFI cases were ≤1 year old,were common adverse reactions,and occurred within 48 hours after vaccination. Conclusions All of the polio vaccines were safe; the AEFI incidence rate of bOPV was higher than that of tOPV. We need to strengthen monitoring safety of polio vaccines.更多还原