Objective To investigate the changes of interferon-γ( IFN-γ) and C-reactive protein( CRP) in cerebrospinal fluid( CSF) and the diagnostic significance in patients with central nervous system infection. Methods A total of 104 patients with central nervous system infection including 31 cases of tuberculous meningitis,42 cases of viral meningitis and 31 cases of purulent meningitis admitted from February 2014 to March 2016 were selected,and 50 patients with non central nervous system infection at same period w...