【摘要】 目的探讨热高迁移率族蛋白B1(HMGB1)、白细胞介素-6(IL-6)和转化生长因子-β1(TGF-β1)在重度子痫前期(s PE)外周血中的表达。方法采用ELISA方法检测57例重度PE、21例正常晚孕对照组血清中HMGB1、IL-6和TGF-β1的表达。结果与正常晚孕对照组孕妇相比,重度子痫前期组孕妇HMGB1、IL-6、TGF-β1明显升高,差异有统计学意义(P<0.05)。早发型重度子痫前期中HMGB1高于晚发型重度子痫前期,但差异无统计学意义(P>0.05);早发型重度子痫前期中IL-6明显高于晚发型重度子痫前期,TGF-β1明显低于晚发型重度子痫前期,差异有统计学意义(P<0.05)。相关分析表明HMGB1与IL-6成正比,与TGF-β1成反比。结论 HMGB1增加可能参与PE的发病机制,评估细胞因子能有效监测重度子痫前期。更多还原

【Abstract】 Objective To explore the expressions of high mobility group box B1（ HMGB1）,interleukin-6（ IL-6）,and transforming growth factor-β₁ （ TGF-β₁ ） in peripheral blood of patients with severe preeclampsia. Methods ELISA was used to detect the expressions of HMGB1,IL-6,and TGF-β₁ in serum of 57 patients with severe preeclampsia and 21 normal late pregnant women（ control group）. Results Compared with control group,the expressions of HMGB1,IL-6,and TGF-β₁ in severe preeclampsia group increased,there were statistically significant differences（ P < 0. 05）. HMGB1 expression in patients with early-onset severe preeclampsia was higher than that in patients with late-onset severe preeclampsia,but there was no statistically significant difference（ P > 0. 05）. IL-6 expression in patients with early-onset severe preeclampsia was higher than that in patients with late-onset severe preeclampsia,TGF-β₁ expression in patients with early-onset severe preeclampsia was lower than that in patients with late-onset severe preeclampsia,there were statistically significant differences（ P < 0. 05）. Correlation analysis showed that HMGB1 was positively correlated with IL-6,while HMGB1 was negatively correlated with TGF-β₁. Conclusion HMGB1 upregulation may be involved in the pathogenesis of preeclampsia,assessment of cytokines can effectively monitor severe preeclampsia.更多还原