【摘要】 目的探讨柳州地区亚甲基四氢叶酸还原酶(MTHFR)基因多态性与不良妊娠结局的相关性。方法选取2013年10月-2015年4月在柳州市妇幼保健院妇科门诊就诊,曾有不良妊娠结局的260例育龄期女性为病例组,健康早孕的203例育龄期女性为对照组。对MTHFR C677T、A1298C的基因多态性进行分型,并运用统计软件对分布特点进行分析。结果与C677T的CC型相比,携带CT型、TT型和CT+TT型基因型的女性发生不良妊娠结局的风险增高(均P<0.05);与A1298C的AA型相比,携带CC型和AC+CC型不良妊娠结局风险增高(均P<0.05)。结论 MTHFR基因多态性在不良妊娠结局的病理和生理机制中发挥重要作用,携带突变基因会增加发生不良妊娠结局的风险。更多还原

【Abstract】 Objective To explore the correlation between methylenetetrahydrofolate reductase( MTHFR) gene polymorphisms and adverse pregnancy outcomes in Liuzhou region. Methods A total of 260 women of childbearing age with adverse pregnancy outcomes history were selected from the hospital from October 2013 to April 2015 as case group; 203 healthy early pregnant women of childbearing age were selected as control group. MTHFR C677 T and A1298 C gene polymorphisms were classified,and the distribution characteristics were analyzed by statistical software. Results Compared with the women with C677 T CC genotype,the risk of adverse pregnancy outcomes in the women with CT,TT,and CT+TT genotypes increased significantly( all P<0. 05). Compared with the women with A1298 C AA genotype,the risk of adverse pregnancy outcomes in the women with CC and AC+CC increased significantly( all P<0. 05). Conclusion MTHFR gene polymorphisms play important roles in pathological and physiological mechanism of adverse pregnancy outcomes,carrying the mutant genes may increase the risk of adverse pregnancy outcomes.更多还原