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心肺复苏患者血清和肽素水平的临床意义

Clinical significance of serum copeptin levels in the patients receiving cardiopulmonary resuscitation

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【作者】 项公强夏晓乐张万里吴显春许德忠王国胜

【Author】 XIANG Gongqiang;XIA Xiaole;ZHANG Wanli;WU Xianchun;XU Dezhong;WANG Guosheng;Department of Emergency, the First People’s Hospital of Longwan District of Wenzhou City in Zhejiang Province;Department of Laboratory, the First People’s Hospital of Longwan District of Wenzhou City in Zhejiang Province;

【机构】 浙江省温州市龙湾区第一人民医院急诊科浙江省温州市龙湾区第一人民医院检验科

【摘要】 目的探讨心脏骤停患者心肺复苏(cardio-pulmonary resuscitation,CPR)不同时间点血清和肽素水平及变化与近期预后的关系。方法分别检测175例心脏骤停患者在CPR 5 min、15 min、恢复自主循环(restoration of spontaneous circulation,ROSC)成功或失败时等不同时间点血清和肽素水平。以ROSC成功或者失败进行分组,比较两组之间血清和肽素水平的差异,并综合两组间的性别、年龄、心脏骤停时间、病因等影响因素进行多因素回归分析。结果 ROSC成功组患者血清和肽素水平[分别为(15.21±3.01)pmol/L、(20.12±5.10)pmol/L、(25.50±8.24)pmol/L]显著高于ROSC失败组患者[分别为(11.25±3.72)pmol/L、(12.63±3.61)pmol/L、(13.51±4.05)pmol/L](P<0.01);血清和肽素水平与ROSC成功率具有显著相关性(P<0.05)。结论检测血清和肽素水平有助于预测心肺骤停患者ROSC成功率。

【Abstract】 Objective To investigate the relationship between serum copeptin level and its changes and short-term prognosis of cardiopulmonary resuscitation(CPR) at different time points in the patients with cardiac arrest. Methods Levels of serum copeptin in 175 patients with cardiac arrest were measured at 5 minutes and 15 minutes of CRP, and at success or failure of restoration of spontaneous circulation(ROSC). The patients were assigned to groups according to ROSC success or failure, and the differences in serum copeptin levels were compared between the two groups. The influencing factors such as gender, age, cardiac arrest time, and etiology were summarized in the two groups to perform multivariate regression analysis. Results Serum copeptin levels in the ROSC success group[(15.21±3.01)pmol/L,(20.12±5.10)pmol/L,(25.50±8.24)pmol/L respectively] were significantly higher than those in the ROSC failure group [(11.25±3.72)pmol/L,(12.63 ±3.61)pmol/L,(13.51 ±4.05)pmol/L respectively](P <0.01); serum copeptin levels were significantly correlated with ROSC success rate(P<0.05). Conclusion The detection of serum copeptin levels can help to predict the success rate of ROSC in patients with cardiopulmonary arrest.

【关键词】 心肺复苏和肽素预后
【Key words】 Cardiopulmonary resuscitation(CPR)CopeptinPrognosis
【基金】 浙江省首届医坛新秀对象基金资助项目(N201374);浙江省温州市龙湾区(高新区)科技发展计划项目(2015R6)
  • 【文献出处】 中国现代医生 ,China Modern Doctor , 编辑部邮箱 ,2017年10期
  • 【分类号】R459.7
  • 【被引频次】2
  • 【下载频次】35
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