【摘要】 目的探讨心脏骤停患者心肺复苏(cardio-pulmonary resuscitation,CPR)不同时间点血清和肽素水平及变化与近期预后的关系。方法分别检测175例心脏骤停患者在CPR 5 min、15 min、恢复自主循环(restoration of spontaneous circulation,ROSC)成功或失败时等不同时间点血清和肽素水平。以ROSC成功或者失败进行分组,比较两组之间血清和肽素水平的差异,并综合两组间的性别、年龄、心脏骤停时间、病因等影响因素进行多因素回归分析。结果 ROSC成功组患者血清和肽素水平[分别为(15.21±3.01)pmol/L、(20.12±5.10)pmol/L、(25.50±8.24)pmol/L]显著高于ROSC失败组患者[分别为(11.25±3.72)pmol/L、(12.63±3.61)pmol/L、(13.51±4.05)pmol/L](P<0.01);血清和肽素水平与ROSC成功率具有显著相关性(P<0.05)。结论检测血清和肽素水平有助于预测心肺骤停患者ROSC成功率。更多还原

【Abstract】 Objective To investigate the relationship between serum copeptin level and its changes and short-term prognosis of cardiopulmonary resuscitation(CPR) at different time points in the patients with cardiac arrest. Methods Levels of serum copeptin in 175 patients with cardiac arrest were measured at 5 minutes and 15 minutes of CRP, and at success or failure of restoration of spontaneous circulation(ROSC). The patients were assigned to groups according to ROSC success or failure, and the differences in serum copeptin levels were compared between the two groups. The influencing factors such as gender, age, cardiac arrest time, and etiology were summarized in the two groups to perform multivariate regression analysis. Results Serum copeptin levels in the ROSC success group[(15.21±3.01)pmol/L,(20.12±5.10)pmol/L,(25.50±8.24)pmol/L respectively] were significantly higher than those in the ROSC failure group [(11.25±3.72)pmol/L,(12.63 ±3.61)pmol/L,(13.51 ±4.05)pmol/L respectively](P <0.01); serum copeptin levels were significantly correlated with ROSC success rate(P<0.05). Conclusion The detection of serum copeptin levels can help to predict the success rate of ROSC in patients with cardiopulmonary arrest.更多还原