【摘要】 亚临床甲状腺功能减退症(亚临床甲减)是指血清中促甲状腺素水平升高但不伴有甲状腺激素水平的异常。虽然亚临床甲减无明显临床表现,但是它却影响机体多个器官的功能。2型糖尿病(T2DM)患者亚临床甲减的发生率高于一般人群,高达2.2%~17.0%。亚临床甲减通过影响内皮功能、血脂水平及动脉粥样硬化的发生与糖尿病心血管疾病的关系已经明确,但是亚临床甲减是否会增加T2DM微血管并发症的发病目前仍有争议,国内外学者针对亚临床甲减与糖尿病视网膜病变及糖尿病肾病的关系进行了相关研究,但报道结果不尽相同。因此,现就亚临床甲减与糖尿病微血管并发症(糖尿病视网膜病变及糖尿病肾病)的关系进行综述。更多还原

【Abstract】 Subclinical hypothyroidism(SCH) is typically defined as elevated thyroid-stimulating hormone(TSH) of serum concentration but with normal serum thyroxin levels. Even though SCH usually shows an asymptomatic state, it indeed affects almost every organ in the body. The pathogenesis of SCH is related to endothelial dysfunction, hyperlipidemia and atherosclerosis, which increase the risk of cardiovascular disease. Moreover, the association between subclinical hypothyroidism and type 2 diabetes mellitus(T2DM)is debatable, with the reported prevalence of SCH in diabetes ranged from 2.2% to 17.0%. However, the association between SCH and diabetes-related microvascular complications remains unclear. Recently,several studies have attempted to investigate the association between SCH and microvascular complications in T2 DM, but the results are varied or even inconsistent. Therefore, this review aims to evaluate the relationship between TSH levels and microvascular complications in type 2 diabetic subjects.更多还原