AIM:To observed the protective effect of diminazene aceturate(DIZE),an angiotensin-converting enzyme 2(ACE2) activator,on diabetic nephropathy(DN) rats.METHODS:Male Wistar rats(n =30) were randomly divided into normal control(NC) group,DN group and DIZE group(each group consisted of 10 rats).The rats in DN group and DIZE group were induced by intraperitoneal injection of streptozotocin at dose of 65 mg/kg.After 12 weeks,the rats in DIZE group and DN group received subcutaneous injection of DIZE(15 mg·kg~(-1...
【基金】
国家自然科学基金资助项目(No.81170207)
【更新日期】
2017-03-31
【分类号】
R587.2;R692.9
【正文快照】
pression of collagen I,FN,TGF-β1 and VCAM-1 in DN group and DIZE group were increased.However,after treatmentof the DN rats with DIZE,these indicators were decreased except the KW/BW.The GLU showed no significant change.CONCLUSION:DIZE raised the activit
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