【摘要】 目的探讨早期新生儿发生重度高胆红素血症的危险因素。方法回顾性分析2014年10月至2015年9月我科收治的314例早期新生儿高胆红素血症病例(重度组53例、轻中度组26I例)的临床资料,分析可能造成重度高胆红素血症的危险因素。结果多因素Logistic回归分析显示:生后体质量下降>5%(OR值21.685,95%CI 6.53~72.009)、母婴血型不合(OR值2.208,95%CI 1.053~4.628)、头皮血肿(OR值3.08,95%CI 1.406~6.749)、产后早期离院(OR值0.377,95%CI0.246~0.578)及看护人对新生儿黄疸认识不足(OR值3.64,95%CI1.52~8.717)两组具有统计学差异,为引起早期新生儿重度高胆红素血症的危险因素。结论生后体质量明显下降、母婴血型不合、头皮血肿、产后住院时间短及看护人对该病认识不足是引起新生儿早期高胆红素血症的危险因素。加强产后新生儿的随访监测和对该病知识的普及可能会减少重度高胆红素血症的发生。更多还原

【Abstract】 Objective To explore the risk factors of severe hyperbilirubinemia in early neonates.Methods Clinical data of 53 cases of early neonates with series hyperbilirubinemia and 261 cases of early neonates with mild and moderate hyperbilirubinemia were retrospectively analyzed from October 2014 to September2015.The risk factors of series hyperbilirubinemia were filtered.Results Multivariate logistic regression analysis showed postnatal excessive loss of weigh(OR 21.685,95%CI 6.53~72.009),incompatibility of blood group between mothers and neonates(OR 2.208,95%CI 1.053~4.628),hematoma of scalp(OR3.08,95%CI 1.406~6.749),early discharge(OR 0.377,95%CI 0.246~0.578) and lack of awareness of jaundice(OR 3.64,95%CI 1.52~8.717)were risk factors of series hyperbilirubinemia in early neonates.Conclusions Postnatal excessive loss of weigh,incompatibility of blood group between mothers and neonates,hematoma of scalp,early discharge and lack of awareness of jaundice were risk factors of series hyperbilirubinemia in early neonates.Strengthening the postnatal monitoring and the popularization of the knowledge of neonatal jaundice maybe can reduce the occurrence of severe hyperbilirubinemia in early neonates.更多还原