【摘要】 目的研究郑州地区献血者人群中HCV阳性与HLA多态性的相关性。方法本研究将丙型肝炎病毒抗体ELISA检测为阳性的119例献血者为研究对象,并以3874例健康造血干细胞捐献者为对照,采用PCR-SS0法对两组HLA-A、B、DRB1基因进行分型。通过SPSS18.0比较分析两组研究对象间HLA等位基因频率分布差异,以找出HLA多态性和病毒性丙型肝炎的相关性,结果 A*25、A*29、A*31、A*32、B*39在HCV抗体阳性组中频率较高。结论在HCV感染机体时,A*25、A*29、A*31、A*32、B*39可能是促进感染发生的基因。更多还原

【Abstract】 Objective Study on the correlation between HCV and HLA gene polymorphism in blood donors of Zhengzhou area. Methods A total of 119 blood donors whose HCV were positive tested by ELISA and 3874 healthy volunteer donors were analyzed from Zhengzhou area, among whom the HLA alleles were detected using PCR-SSO. Moreover,SPSS18.0 software was applied to compare the difference between these two groups. Results A*25、A*29、A*31、A*32、B*39 were significantly higher in donors group which HCV were positive tested. Conclusion A*25、A*29、A*31、A*32、B*39 might promote hosts susceptible to HCV infection.更多还原