【摘要】 目的探讨小细胞肺癌(SCLC)患者血清胃泌素释放肽前体(Pro-GRP)的水平及意义。方法回顾分析60例SCLC患者和120例肺部良性病变患者的临床病理资料,分别作为SCLC组和良性组;同期体检健康者100例作为对照组。所有入组对象均进行血清Pro-GRP和神经元特异性烯醇化酶(NSE)检测,比较组间差异;以阳性标准Pro-GRP>77.8 pg/ml,NSE>16.3 ng/ml判断,比较不同诊断方法的灵敏度、特异度;比较SCLC患者不同分期及不同治疗效果患者Pro-GRP、NSE水平差异。结果 SCLC组血清Pro-GRP、NSE明显高于良性组和健康组(P<0.05)。Pro-GRP诊断SCLC的灵敏度为80.00%,高于NSE(P<0.05),ProGRP+NSE诊断SCLC的灵敏度为98.33%,高于Pro-GRP、NSE(P<0.05)。SCLC广泛期患者Pro-GRP、NSE高于SCLC局限期(P<0.05);SCLC治疗后缓解期、好转期的Pro-GRP、NSE低于治疗前,且缓解期低于好转期(P<0.05);治疗后进展期患者Pro-GRP、NSE高于治疗前(P<0.05)。结论 SCLC患者血清ProGRP水平呈高表达,其诊断SCLC的灵敏度高于NSE,并与肿瘤的分期及预后存在相关性。更多还原

【Abstract】 Objective To investigate the clinical value of diagnostic and prognosis assessment of pro gastrin-releasing peptide(Pro-GRP) for small cell lung cancer(SCLC). Methods Totally 60 cases of SCLC(SCLC group) and 120 cases of benign lung lesions(benign group) were analyzed retrospectively, and 100 healthy were selected as control group. and the pro gastrin-releasing peptide(ProGRP) and neuron-specific enolase(NSE) were detected and compared between the three groups. The sensitivity and specificity of Pro-GRP and NSE were analyzed with the positive standard Pro-GRP>77.8 pg/ml, NSE>16.3 ng/ml. The differences of Pro-GRP and NSE levels in different stages and different therapeutic effects of SCLC patients were compared. Results The levels of Pro-GRP and NSE in SCLC group were significantly higher than those in benign group and control group(P<0.05). The sensitivity of Pro-GRP were 80.00%, which was higher than NSE in diagnosis of SCLC(P<0.05). The sensitivity of Pro-GRP combined with NSE in diagnosis of SCLC was 98.33%,which was significantly higher than that of Pro-GRP and NSE(P<0.05). The levels of Pro-GRP and NSE in SCLC patients of extensive period were significantly higher than those in SCLC patients of limited period(P<0.05). After treatment, the levels of Pro-GRP and NSE in SCLC patients of remission stage and improvement period were significantly decreased(P<0.05), and the remission stage was lower than the improvement period(P<0.05). After treatment, the levels of Pro-GRP and NSE in the SCLC patients of progress period were significantly increased than those before treatment(P<0.05). Conclusion Pro-GRP is high expression in SCLC patients and correlated with the stage and prognosis of SCLC, and its sensitivity for SCLC is higher than NSE.更多还原