【摘要】 目的:了解安徽省立医院南区(以下简称"我院")药品不良反应(adverse drug reaction,ADR)发生的特点和规律,探讨相关对策,为合理用药提供参考。方法:对2016年1—10月我院上报的260例ADR报告中患者的年龄及性别、引发ADR的给药途径及药物种类、ADR累及器官和(或)系统及临床表现等进行回顾性分析。结果:260例ADR患者中,新的ADR 44例(占16.92%),严重的ADR 13例(占5.00%),一般的ADR 207例(占79.62%);60~<70岁者最多。静脉滴注致ADR病例数最多,其次为口服给药。引发ADR病例数排序居前3位的分别为抗肿瘤药、心脑血管系统用药及抗感染药。ADR主要累及消化系统,其次为血液系统、皮肤及其附件。结论:ADR的发生与多种因素相关,临床应加强用药监测,医务人员及患者应增强ADR上报意识,以促进合理用药。更多还原

【Abstract】 OBJECTIVE: To investigate the characteristics and laws of adverse drug reactions( ADR) the Southern District of in Anhui Provincial Hospital( hereinafter referred to as "our hospital"),so as to probe into the relevant countermeasures and provide reference for the rational application of drugs. METHODS: Retrospective analysis was conducted on data of 260 cases of ADR reports in terms of patients ’ age and gender,ADR-inducing route of administration,ADR involved organs and( or) systems reported from Jan. to Oct. 2016 in our hospital. RESULTS:Of the 260 cases of ADR,44 cases( 16. 92%) were new ADR,13 cases( 5. 00%) were severe ADR and 207 cases were general ADR( 79. 62%); patients aged 60-< 70 years were the most common cases. ADR induced by intravenous drip took the lead,followed by oral administration. The top three ADR-inducing drugs were respectively antineoplastic drugs,cardiovascular and cerebrovascular system drugs and anti-infectious drugs. ADR mainly involved digestive system,followed by blood system,skin and accessories. CONCLUSIONS: The occurrence of ADR is related to various factors,the clinicians should strengthen the monitoring on drug application,the medical staff and patients should improve the consciousness of ADR reports,so as to promote the rational drug application.更多还原