【摘要】 目的比较替吉奥+奥沙利铂或卡培他滨+奥沙利铂方案治疗中晚期胃癌患者的效果及不良反应。方法选取四川省人民医院2014年1月至2015年1月经病理或细胞学确诊为不可手术的胃癌患者111例,利用随机抽样分为A、B两组,A组60例,B组51例,A组给予替吉奥+奥沙利铂,一个治疗周期为21天,替吉奥胶囊40 mg/m~2,每日2次,口服,d1~14;奥沙利铂130 mg/m~2,d1,口服。B组给予卡培他滨+奥沙利铂,一个治疗周期为21天,卡培他滨片1000 mg/m~2,口服,每日2次,d1~14;奥沙利铂130 mg/m~2,d1,口服。给药2个周期,用药后及随访期间评价疗效及不良反应。结果两组患者的客观有效率(ORR)、疾病控制率(DCR)均无统计学差异(P>0.05)。两组贫血、乏力、恶心呕吐、肝功能损伤、外周神经炎发生率比较,差异无统计学意义(P>0.05)。A组腹泻与手足综合征发病率低于B组(P<0.05)。结论两种治疗方案用于中晚期胃癌患者均有良好的安全性,疗效相当,替吉奥+奥沙利铂组腹泻和手足综合征发病率低于卡培他滨+奥沙利铂组。更多还原

【Abstract】 Objective To compare the curative effect and adverse reaction of tegafur + oxaliplatin and capecitabine + oxaliplatin for patients with advanced gastric cancer(GC). Methods We selected 111 GC patients who were definitely diagnosed by pathological and cytological examination in Sichuan Provincial People’s Hospital between January 2014 and January 2015. They were randomly divided into group A(n = 60) and group B(n = 51). The group A was treated with tegafur plus oxaliplatin with 21 days-treatment cycle. In one cycle,the patients orally took tegafur capsule 40 mg/m2,2 times daily for d1 ~ 14 and orally took oxaliplatin 130 mg/m2,d1. The group B received capecitabine plus oxaliplatin with a treatment period of 21 days in which the patients orally took capecitabine tablets 1000 mg/m2,2 times daily for d1 ~ 14 and orally took oxaliplatin 130 mg/m2,d1. The efficacy and adverse reactions were evaluated after 2 cycles. Results There was no significant difference in the objective response rate(ORR) and disease control rate(DCR)between the two groups(P > 0. 05). There was also no significant difference in the incidence of anemia,fatigue,nausea and vomiting,liver function injury and peripheral neuritis between the two groups(P > 0. 05). However,the incidence of diarrhea and hand foot syndrome in the group A was lower than that in the group B(P < 0. 05). Conclusion The safety of two types of treatment in patients with advanced gastric cancer is quite good. However,incidence of diarrhea and hand foot syndrome incidence in tegafur + oxaliplatin regimen is lower than that in capecitabine + oxaliplatin regimen.更多还原