【摘要】 达比加群酯是新型的口服直接凝血酶抑制剂,具有强效抗凝、出血风险低、无需特殊监测、药物相互作用少等优点,目前已成为临床研究的热点。该文综述了近年来相关的作用机制、药代动力学、临床应用等方面的研究,为达比加群酯的后续研究提供参考。更多还原

【Abstract】 Dabigatran etexilate is a novel direct oral thrombin inhibitor. The drug has a strong anticoagulant feature,low risk of bleeding,no need for special monitoring,few drug interactions and other advantages and become a hot spot in clinical research. In this paper,the mechanism of action,pharmacokinetics,clinical application and other aspects are reviewed to provide reference for the further research of dabigatran etexilate.更多还原