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钩菊胶囊质量标准研究

Research on quality standard of Gouju Capsules

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【作者】 朱和平韩晓珂王权祁俊

【Author】 ZHU Heping;HAN Xiaoke;WANG Quan;QI Jun;Preparation Room, Wuhu Hospital of TCM;

【机构】 芜湖市中医医院制剂室

【摘要】 目的建立钩菊胶囊的质量标准。方法薄层色谱法对钩藤、淫羊藿进行定性鉴别;UV-HPLC对淫羊藿苷进行含量测定。采用Agilent ZORBAX SB-C18色谱柱(150 mm×4.6 mm,5μm);流动相:乙腈-水(25∶75);流速:1.0 mL/min;柱温:30℃;检测波长为270 nm。结果薄层色谱中斑点清晰,阴性均无干扰;淫羊藿苷在15150μg/mL范围内线性关系良好(r=0.9996),平均回收率为100.9%(RSD=2.77%)。结论本试验结果准确、简便,易控,可作为钩菊胶囊的质量标准。

【Abstract】 Objective To establish the quality standard of Gouju Capsules. Methods The main ingredients of Ramudus Uncaria Cum Uncis, Epimedium were identified by TLC. Content of icariin was determined by UV-HPLC. The content of the berberine was determined by HPLC; the column of Agilent ZORBAX SB-C18(150 mm×4.6 mm, 5 μm) was used.The mobile phase was ocetonitrile-water(25∶75), the column temperature of 30℃, at the flow of 1.0 mL/min and detec tion wavelength was 270 nm. Results The spots on TLC plates were distinct, without interference. A good linearity of icariin was in the ranges of 15-150 μg/mL(r=0.9996). The average recovery was 100.9%(RSD =2.77%). Conclusion The results of this experiment are accurate, simple and easy to control. It can be used as a quality standard for Gouju Capsules.

【关键词】 钩菊胶囊薄层鉴别淫羊藿苷含量测定
【Key words】 Gouju CapsulesTLCIcariinContent determination
  • 【文献出处】 中国医药导报 ,China Medical Herald , 编辑部邮箱 ,2017年28期
  • 【分类号】R286.0
  • 【下载频次】90
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