【摘要】 对一些致命性脑肿瘤(如高度恶性胶质母细胞),可利用新的成像方式(如纳米技术)来提高作为主要治疗方式的外科切除术的成功率。目前,临床上发现可用的新型纳米技术平台有脂质、炭纳米管、超顺磁性纳米粒子、以核酸为基础的纳米粒等。纳米技术用作新型成像工具可提高抗癌药物对肿瘤定位的准确度,同时由于纳米粒子独特的特性可用作药物的运输载体以提高药物的生物利用度。因此,通过总结纳米技术平台在诊断及靶向治疗高度恶性胶质母细胞瘤所取得的优势,可为恶性胶质母细胞瘤的精确治疗与预后存活率提供新的技术突破。更多还原

【Abstract】 For some deadliest human tumors(such as highly malignant glioblastoma),new approaches like nanotechnology can be applied to improve the success rate of the surgical resection.The new nanotechnology platforms used for delivery into the brain tissue include liposomes,carbon nanotubes,superparamagnetic nanoparticles and nucleic acid based nanoparticles etc.Nanotechnology has been used as a new imaging tool,which not only can improve the accuracy of anticancer drugs targeting of the tumor,but also improve the bioavailability due to the unique properties of these nanoparticles to be a good drug carriers.Therefore,a summary of the advantages of nanotechnology in the diagnosis and treatment of highly malignant glioblastoma may provide breakthrough to the accurate treatment and prognostic survival rate.更多还原