【摘要】 目的:分析抗N-甲基-D-天冬氨酸(anti-N-methyl-D-aspartate,NMDA)受体脑炎的发病机制及临床特征,提高该病的诊治水平,减少后遗症。方法:对我院诊治的抗NMDA受体脑炎的临床资料进行回顾性分析,并根据此病例复习相关文献,总结经验。结果:患者因"言语混乱15天,意识不清1天"收入我院。行脑脊液及血液检查抗NMDA受体抗体阳性,给予糖皮质激素、免疫球蛋白、免疫抑制剂治疗,病情较之前显著改善,且任何的后遗症均未留下。结论:抗NMDA受体脑炎在临床上的发病率比较低,我们需提高对此病的认识,减少误诊。更多还原

【Abstract】 Objective To analyze pathogenesis and clinical features of anti-N-methyl-D-aspartate( NMDA) receptor encephalitis in order to improve levels of diagnosis and treatment.Methods Clinical data of one patient with anti-NMDA receptor encephalitis was retrospectively analyzed,and related literature was reviewed. Results The patient was admitted for 15 days of disorders,unconsciousness for 1 day. No abnormalities were found by head CT and Electroencephalogram examination in local psychiatric hospital, considering for separating disorder,given corresponding treatment, the patient’s situation gets no better, otherwise suffered into coma.Then anti-NMDA receptor encephalitis was confirmed both blood and cerebrospinal fluid.Glucocorticoid and immunoglobulin was used in this patient,she was improved obviously.Conclusion AntiNMDA receptor encephalitis is rare in clinic,and the key of avoiding misdiagnosis is to improve understanding of the disease.更多还原