【摘要】 目的:研究表观扩散系数(apparent diffusion coefficient,ADC)与乳腺浸润性导管癌分子生物学标记之间的关系,以指导临床判断预后及选择治疗方案。方法:对67例乳腺浸润性导管癌患者进行磁共振扩散加权成像(diffusion weighted imaging,DWI)检查,并测量病灶ADC值。术后免疫组化分析人表皮生长因子受体2(human epidermal growth factor receptor 2,HER-2)、雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)、Ki-67,统计学分析ADC值与ER、PR、HER-2、Ki-67的相关性,并研究不同分子分型病灶之间ADC值的差别。结果:Spearman相关性分析表明,ADC值与Ki-67之间无相关性(P>0.05);ER、PR、HER-2阴性表达者ADC值高于阳性者(P<0.05);三阴性病灶ADC值明显高于Luminal A型、Luminal B型、HER-2过表达型(P<0.05);HER-2过表达型病灶ADC值高于Luminal B型。结论:ADC值与乳腺浸润性导管癌分子生物标记及分子分型具有相关性,可辅助指导临床选择治疗方案及判断预后。更多还原

【Abstract】 Objective: To investigate the relationship between apparent diffusion coefficient(ADC) value and molecular biomarkers in breast invasive ductal carcinomas(IDCs), which may facilitate the optimal treatment and prognosis prediction.Methods: A total of 67 patients with IDC were enrolled in this study. All the patients underwent breast diffusion weighted magnetic resonance imaging(DW-MRI) before treatment. The ADC values of IDCs were calculated. The expressions of estrogen receptor(ER), progesterone receptor(PR), Ki-67, human epidermal growth factor receptor 2(HER-2) were analyzed by immunohistochemistry. The relationships between ADC values and ER, PR, HER-2 and ki-67 expressions were statistically evaluated while the ADC values in different subtypes were also studied. Results: The ADC values of IDCs did not correlate significantly with Ki-67 by Spearman’s correlation analysis(P>0.05); The mean ADC value was higher in IDCs with negative ER, PR and HER-2 expressions than that with positive expressions(P<0.05); The triple-negative IDC had higher mean ADC value than Luminal A, Luminal B and HER-2 overexpressing IDCs(P<0.05); The mean ADC value in HER-2 overexpressing IDC was significantly higher than that in Luminal B type IDC(P<0.05). Conclusion: The ADC value could be used to evaluate the expressions of molecular biomarkers and IDC subtype, which could help determine individual treatment and predict prognosis.更多还原