【摘要】 目的:利用功能磁共振成像及认知功能测试研究青少年双相障碍(PBD)缓解相脑功能及认知功能改变状况。方法:采集PBD缓解相患者及正常青少年的功能磁共振成像信号(各16例),计算信号低频振幅,对被试进行认知功能测试,并分析两者的相关性。结果:与对照组相比,PBD缓解相组的低频振幅数值在右侧小脑、右侧颞上回及左侧海马旁回显著增加,在左侧枕中回、左侧楔叶及右侧枕上回显著降低(P<0.01,FDR校正)。右侧小脑与Stroop1测试结果负相关,左侧枕中回与数字广度-倒背测试结果正相关。结论:PBD缓解相会出现颞叶、小脑、边缘系统及枕叶自发神经活动紊乱,且小脑和枕中回的异常与PBD缓解相认知功能损伤有关。更多还原

【Abstract】 Objective To investigate the alteration of brain function and cognitive function between remitted patients with pediatric bipolar disorder(PBD) and healthy adolescents by using resting-state functional magnetic resonance imaging(f MRI)and cognitive function tests. Methods The f MRI signals of 16 PBD-remitted patients and 16 healthy controls were collected,and the amplitude of low-frequency fluctuation(ALFF) was calculated. Cognitive function tests were performed for all subjects. Correlations between results of cognitive function tests and ALFF were analyzed. Results Compared with control group, ALFF in PBD-remitted patients significantly increased in the right cerebellum, the right superior temporal gyrus, the left parahippocampal gyrus, while decreased in the left middle occipital gyrus, the left cuneus and the right superior occipital gyrus(P<0.01, FDR correction). ALFF in the right cerebellum was negatively correlated to the results of Stroop1 test and ALFF in the left middle occipital gyrus was positively correlated to the results of backward digit span test. Conclusion PBD-remitted patients show spontaneous neural activity disorders in the temporal lobe, cerebellum, limbic system and occipital lobe. The dysfunctions of cerebellum and middle occipital gyrus are related to cognitive impairment of PBD-remitted patients.更多还原