【摘要】 目的:分析我院2013~2015年抗癫痫药物血药浓度监测(TDM)结果,为临床合理用药提供参考。方法:采用回顾性研究方法,收集1 098例次患者使用丙戊酸钠、卡马西平、苯巴比妥的TDM数据并进行统计分析。结果:1 098例次TDM结果中丙戊酸钠1 009例次,卡马西平65例次,苯巴比妥24例次,3种药品血药浓度在推荐范围内的比例分别为42.6%,64.6%,37.6%。联合用药共31例次,药物浓度均在推荐浓度范围内的8例次(25.8%)。末次给药和采血时间对TDM结果有明显影响。结论:抗癫痫药物血药浓度个体差异大,影响因素多,临床用药应综合考虑各方面因素,实施个体化给药方案,确保用药安全有效。更多还原

【Abstract】 Objective: To analyze the results of therapeutic drug monitoring( TDM) from 2013 to 2015 in our hospital were analyzed,so as to provide rational clinical use of drug. Methods: Retrospective analysis method was used,the TDM of serum concentrations of valproate sodium,carbamazepine and phenobarbital used in 1 098 cases were collected,statistical analysis was conducted. Results: Among the 1 098 cases,the numbers of patients used valproate sodium,carbamazepine and phenobarbital were 1 009,65 and 24,each ratio of concentration in recommended range was 42. 6%,64. 6%,37. 6%,respectively. The total of the combination drug use was 31 cases,8 patients with effective concentration of all drugs( 25. 8%). The time of last last administration and blood sampling had great influence on the results of TDM. Conclusion: The effective concentration of anti-epilepsy drugs varied in different patients and many factors were included. Clinicians should consider the use of drugs comprehensively,and make personalized medicine scheme to improve rational drug use and safety.更多还原