【摘要】 三氧化二砷（As₂O₃）是一种古老的毒性药物,现已经作为一种新药被应用到临床。As₂O₃对多种肿瘤都显示出很好的治疗效果,尤其是对于急性早幼粒细胞白血病（APL）的治疗。研究表明,As₂O₃对各个阶段的APL患者都起到缓解作用,As₂O₃已被美国食品和药品监督管理局批准用于治疗APL。但As₂O₃的临床应用却由于其毒性作用受到限制,其中以心脏毒性作用最为显著。本文将对As₂O₃抗治白血病作用和毒性作用做一综述,为As₂O₃在临床上应用提供依据。更多还原

【Abstract】 Arsenic trioxide（As₂O₃） has been considered a poison, which is also known as an old drug and has recently been re-introduced as a new medicine. As₂O₃ shows potent effect on many types of cancers, especially on a specific types of leukemia-acute promyelocytic leukemia（APL）. This poison drug As₂O₃ is effective against all stages of APL and has been approved by the Food and Drug Administration（FDA） of the United States for the treatment of APL. However, the clinical use of As₂O₃ has been limited by its toxicities, especially cardiotoxicity. This review focuses on the therapeutic effect on APL and the side effect during treatment.更多还原