Chiral spirooxindole γ-lactones with three stereogenic centres are rare. An efficient asymmetric construction of novel spiro-fused 2-oxindole/α-methy-paraconnic ester is reported, which was offered via organocatalytic Michael reaction of propaldehyde and olefinic oxindoles, with subsequent H_2O_2/K_2CO_3 system-mediated α-hydroxylation/hemiacetalization cascade reaction under oil/water two-phase conditions, and final oxidative γ-lactonization by pyridinium chlorochromate(PCC). The presented strategy feature...
【基金】
国家自然科学基金(No.21402176)资助项目~~
【更新日期】
2017-12-11
【分类号】
O626
【正文快照】
*Corresponding author.E-mail:xiaaibao@zjut.edu.cnReceived March 6,2017;revised May 24,2017;published online June 2,2017.Project supported by the National Natural Science Foundation of China(No.21402176).螺环氧化吲哚核心骨架广泛地存在于天然产物和临床药物之
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