A chiral prosthetic group induced heterogeneous diastereoselective asymmetric hydrogenation of β-dehydroamino esters, catalyzed by Pt/Al_2O_3, has been developed. A series of β-dehydroamino esters were successfully hydrogenated in high yields with good diastereoselectivities(dr up to 5.2∶94.8). This method provides a convenient and efficient synthetic way for the preparation of chiral β-amino acid derivatives, which are key intermediates for bioactive compounds and pharmaceuticals.
【基金】
supported by the National Natural Sciences Foundation of China(No.21472124)~~
【更新日期】
2017-07-27
【分类号】
O621.251
【正文快照】
*Corresponding author.E-mail:zhaoguo@sjtu.edu.cnReceived January 9,2017;revised February 28,2017;published online March 3,2017.Project supported by the National Natural Sciences Foundation of China(No.21472124).Enantiomerically pureβ-amino acids and thei
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