An efficient and practical N-iodosuccinimide-promoted regioselective arylsulfenylation of imidazo[1,2-a]pyridines with disulfides has been developed to afford functionalized 3-sulfenylimidazo[1,2-a]pyridines heterocycles in moderate to good yields. Their structures were confirmed by IR, ~1H NMR, ~(13) C NMR and HRMS. Furthermore, this method has the advantages of mild reaction conditions, broad substrates scope and environmentally benign. Notably, the current methodology could also be conveniently applied t...