【摘要】 目的探讨β₁肾上腺素能受体（β₁-AR）常见基因多态性对高血压病患者左心室肥厚的影响。方法高血压病患者114例分为合并左心室肥厚（EH-LVH组,50例）和不合并左心室肥厚者（EH组,64例）两组,对照组为同期正常体检者54例。采用聚合酶链反应-限制性片段长度多态性检测β₁-AR Gly389Arg和Ser49Gly位点的单核苷酸基因多态性。结果EH-LVH组患者β₁-AR Arg389Arg基因型比例高于EH组和对照组（86.0%vs.65.6%和51.9%）（P<0.05）;EH-LVH组β₁-AR Arg389等位基因频率高于EH组和对照组（90.0%vs.78.1%和71.2%）（P<0.05）。三组β₁-AR Ser49Gly基因型和等位基因频率差异无统计学意义（P>0.05）。结论携带β₁-AR Arg389等位基因的高血压病患者更易出现左心室肥厚。更多还原

【Abstract】 Objective To investigate the influence of genetic polymorphisms ofβ₁-adrenergic receptor（β₁-AR）on the left ventricular hypertrophy（LVH）in the patients with essential hypertension（EH）.Methods The polymorphisms ofβ₁-AR Gly389 Arg and Ser49 Gly allele genes were detected by polymerase chain reaction-restriction fragment length polymorphism technology in 50 EH patients with LVH（group A）,64 EH patients without LVH（group B）and 54 healthy people（group C）.Results The percentage of patients carryingβ₁-AR Arg389 Arg genotype was higher in group A than that in groups of B and C（86.0% vs.65.6% and 51.9%）（P<0.05）.The allele gene frequency ofβ₁-AR Arg389 was higher in group A than that in groups of B and C（90.0% vs.78.1% and 71.2%）（P<0.05）.The percentage of patients carryingβ₁-AR Ser49 Gly genotype and the allele gene frequency were not significantly different among three groups（P>0.05）.Conclusion The EH patients carrying Arg389 allele gene run a higher risk for the LVH.更多还原