Objective To investigate the regulation of HLA-G expression by miR-133 a in JEG-3 cells. Methods The trophblastic JEG-3 cells were transfected with pre-miR-133 a or pre-miR-133 a inhibitor. miR-133 a mRNA,HLA-G mRNA and HLA-G protein were detected in the transfected JEG-3 cells using RT-PCR and Western blot.Results In cells transfected with pre-miR-133 a,miR-133 a significantly increased,and HLA-G mRNA and protein significantly decreased,compared with cells treated with pre-miR-133 a inhibitor( P < 0. 05). ...
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