【摘要】 目的探讨颅脑损伤急性期凝血常规及D-二聚体(D-Dimer)变化与病情发展的关系。方法选取我院收治的131例急性颅脑损伤患者,按病情程度不同分为A组(67例)和B组(64例),A组患者为急性轻型颅脑损伤,B组患者为急性重型颅脑损伤;同期选取于我院体检健康的60名志愿者作为C组。采集三组研究对象在入院时的血液样本进行凝血功能与D-二聚体检查并将三组结果进行对比。结果与A、C两组比较,B组患者D-Dimer显著升高,而Fbg明显下降(P<0.05)。与预后良好的患者比较,预后较差的患者的Fbg明显降低,D-Dimer显著升高(P<0.05),而三组的PT、APTT和TT比较差异无统计学意义(P>0.05)。结论凝血常规及D-Dimer等指标变化与颅脑损伤的病情发展程度呈正相关,可作为诊断急性颅脑损伤程度的重要指标,为临床治疗及预后恢复提供可靠的依据。更多还原

【Abstract】 Objective To explore the correlation between the changes of coagulation indicators, D-dimer and the disease development of acute stage of cerebral injury. Methods 131 cases of patients with acute cerebral injury admitted to our hospital were selected and divided into group A(67 cases) and group B(64 cases) according to different conditions of disease. Patients in group A had slight acute cerebral injury, and patients in group B had severe acute cerebral injury. 60 healthy volunteers with physical examination in our hospital at the same period were selected as group C. The blood samples in three groups were collected on admission and given coagulation function and D-dimer examinations. The results were compared among three groups. Results Compared with group A and group C, D-dimer of group B significantly increased, and Fbg significantly decreased(P <0.05). Compared with the patients with poor prognosis, Fbg of patients with good prognosis significantly decreased, and D-dimer significantly increased(P <0.05). No statistical difference was found in PT, APTT and TT among the three groups(P >0.05). Conclusions The changes of coagulation indicators and D-dimer have positive correlation with the development of cerebral injury, which can be used as important indicators for diagnosing the degree of acute cerebral injury, so as to provide reliable reference for clinical treatment and recovery of prognosis.更多还原