【摘要】 目的系统评价加替沙星对比左氧氟沙星治疗细菌性结膜炎疗效与安全性。设计系统综述。研究对象检索中国生物医学文献数据库、中国期刊全文数据库(CNKI)、万方医药期刊全文数据库、中文科技期刊数据库、Pub Med、Cochrane Library、Embase。收集加替沙星对比左氧氟沙星治疗细菌性结膜炎的临床随机对照研究(RCT)。方法根据纳入和排除标准筛选文献,对符合条件的RCT由两位研究者独立进行资料提取和质量评价后,采用Cochrane协作网提供的Rev Man 5.3与Stata12.0进行Meta分析。主要指标治愈率、痊愈率、不良反应。结果加替沙星组治愈率(OR=3.20,95%CI为2.37~4.31,P<0.00001)与痊愈率(OR=1.88,95%CI为1.56~2.27,P<0.00001)较左氧氟沙星组均较高,并能降低总不良反应的发生(OR=0.47,95%CI为0.27~0.80,P=0.006)。而眼睛刺痛(OR=0.76,95%CI为0.37~1.57,P=0.46)、眼痒(OR=0.32,95%CI为0.10~1.00,P=0.05)等不良反应指标在两组中无差异。结论加替沙星在治疗细菌性结膜炎方面,与左氧氟沙星相比疗效好,不良反应少。更多还原

【Abstract】 Objective To assess the efficacy and safety of gatifloxacin and levofloxacin in treating bacterial conjunctivitis by conducting a meta-analysis. Design Systemic review. Participants Collected randomized clinical controlled studies(RCTs) of gatifloxacin versus levofloxacin in the treatment of bacterial conjunctivitis, which were retrieved from Chinese Biomedical Database, Chinese periodical full text database(CNKI), Wan-fang database, Database of Chinese Periodicals of Science and Technology, Pub Med, Cochrane Library and Embase. Methods According to the inclusion and exclusion criteria, data extraction and quality assessment were done by two researchers independently, and clinically important measures were selected. Outcomes were pooled with Revman5.3 and Stata 12.0.Main Outcome Measures Curative ratio, healing rate, adverse reactions. Results The curative ratio(OR=3.20, 95%CI=2.37~4.31,P<0.00001) and healing rate(OR=1.88, 95%CI=1.56~2.27, P<0.00001) of gatifloxacin group was better than the levofloxacin, and tends to be less total adverse reactions(OR=0.47, 95%CI=0.27~0.80, P=0.006). Eyes prick(OR=0.76, 95%CI=0.37~1.57, P=0.46) and eye itch(OR=0.32, 95%CI=0.10~1.00, P=0.05) were non-statistical significance among two groups. Conclusion In the treatments of bacterial conjunctivitis, gatifloxacin has better efficacy and safety with higher curative ratio and healing rate, and less adverse reactions.更多还原