【摘要】 目的探讨老年餐后低血压患者与轻度认知功能障碍(MCI)的关系。方法老年住院患者296例,年龄60~95(78.95±8.18)岁,其中男性194例(65.5%)。每隔30 min测量三餐后2 h内血压,根据是否符合餐后低血压(PPH)标准分为对照组和PPH组。采用协和版蒙特利尔认知评估量表(Mo CA-P)评估其认知功能,根据MCI诊断标准分为认知功能正常(NC)组和MCI组。分析PPH与MCI的关系。结果 296例患者中,符合PPH标准有146例(49.3%),MoCA得分低于分界值有125例(42.2%)。PPH组MoCA得分低于非PPH组(24.76±3.96比25.66±2.98,P=0.028)。PPH组MCI发生率高于非PPH组(50.7%比34%,P=0.005)。Logstic回归分析显示,年龄、受教育年限和PPH与MCI独立相关[OR(95%CI)分别为1.06(1.02~1.11),0.83(0.76~0.90),1.98(1.16~3.36),均P<0.05]。结论 PPH可能是老年患者轻度认知功能障碍的独立危险因素。更多还原

【Abstract】 Objectives To explore the relationship between postprandial hypotension( PPH) and mild cognitive impariment( MCI) in elderly patients. Methods 296 senile inpatients with mean age of78. 95 years( range from 60 to 95 years) were recruited. 194 patients were male( 65. 5%). Their postprandial blood pressures were measured every 30 minutes,and then divided into 2 groups according to the definition of PPH: PPH group and non-PPH group. Cognitive function was assessed by Peking Union Medical College Hospital vision of Montreal Cognitive Assessment( Mo CA-P),then divided into 2 groups according to the definition of MCI: MCI group and normal cognition( NC) group. Results There are 146 patients met PPH criteria( 49. 3%). 125 patients had MCI( 42. 2%). Compared with the non-PPH group,the PPH group had lower Mo CA score( 24. 76 ± 3. 96 vs 25. 66 ± 2. 98,P = 0. 028). The incidence of MCI in PPH group was significantly higer than in non-PPH group( 50. 7% vs 34%,P = 0. 005). Logistic regression analysis showed that age,average education years and PPH independently correlated with MCI[OR( 95% CI) was 1. 06( 1. 02-1. 11),0. 83( 0. 76-0. 90),1. 98( 1. 16-3. 36) respectively,all P < 0. 05].Conclusion PPH may be an independent risk factor for MCI in elderly patients.更多还原