【摘要】 目的探讨急性心肌梗死（AMI）患者合并非甲状腺病态综合征（NTIS）时FT₃水平对患者远期死亡率的影响。方法共纳入1 809例AMI患者,按甲状腺功能检查分为NTIS组和甲功正常组,随访1⁸.5年,采用多因素COX回归分析方法,研究FT₃水平对AMI患者远期全因死亡、心血管死亡的影响。结果 AMI患者中NTIS的发生率为21.7%。与甲功正常组相比,NTIS组住院死亡率、远期全因死亡率和远期心血管死亡率均升高（14.3%vs.1.8%,23.1%vs.14.5%,14.0%vs.7.6%,P<0.05）。FT₃水平（HR=0.304,95%CI:0.134⁰.693,P=0.005）与AMI患者远期全因死亡的独立相关,FT₃水平（HR=0.241,95%CI:0.093⁰.622,P=0.003）也是AMI患者远期心血管死亡的独立危险因素。结论 AMI患者中常见NTIS,FT₃水平是AMI患者远期全因死亡和心血管死亡的独立危险因素。更多还原

【Abstract】 Objective To investigate the effect of FT₃ on the long-term mortality of patients with acute myocardial infarction（ AMI） complicated with non-thyroidal illness syndrome（ NTIS）.Methods A total of 1 809 patients with AMI were divided into NTIS group and normal group. The patients were followed up for 1 to 8. 5 years. The multivariate COX regression analysis was used to study the effect of FT₃ on long-term all-cause mortality and cardiovascular mortality in AMI patients.Results The incidence rate of NTIS in AMI patients was 21. 7%. Compared with the normal control group,the in-hospital mortality,long-term all-cause mortality and long-term cardiovascular mortality in the NTIS group were significantly higher（ 14. 3% versus 1. 8%,23. 1% versus 14. 5%,14%versus 7. 6%,P < 0. 05）. The level of FT₃（ HR = 0. 304,95% CI: 0. 134 0. 693,P = 0. 005）was correlated with long-term all-cause mortality in patients with AMI,and FT₃ level（ HR = 0. 241,95% CI: 0. 093-0. 622,P = 0. 003） is an independent risk factor for long-term cardiovascular death in patients with AMI. Conclusion NTIS exists in AMI commonly. FT₃ level is an independent risk factor for long-term all-cause death and cardiovascular death in patients with AMI.更多还原