【摘要】 别嘌醇诱导的药物超敏反应综合征(DRESS),是一种急危重的系统性药物超敏反应,由于病初常以迟发型皮疹为首要临床表现,常会误诊或者因缺乏足够的重视而治疗不充分导致病情恶化。该文报道1例别嘌醇相关的DRESS,以全身多发红色斑丘疹、发热、多发淋巴结肿大、嗜酸性粒细胞升高、HLA-B~*5801阳性、多脏器受累为临床表现,病初因不够重视导致病情加重,随后经积极适当的治疗,最后痊愈。该文提示别嘌醇诱导的DRESS的早期诊断、治疗对于疾病的控制十分重要,HLA-B*5801基因的检测对于疾病的诊断具有一定的积极意义。更多还原

【Abstract】 Allopurinol-induced drug reaction with eosinophilia and systemic symptoms( DRESS)syndrome is an acute and severe form of systemic drug-induced hypersensitivity syndrome. During the early onset of DRESS,it is initially manifested with delayed rash. It is likely to deteriorate due to misdiagnosis and insufficient treatment. In this article,we reported one case of allopurinol-induced DRESS with clinical manifestations including systemic multiple erythematosus rash,fever,multiple lymph node enlargement,eosinophilia,positive HLA-B* 5801 and multi-organ dysfunctions. The condition of the patient deteriorated due to insufficient attention during the early onset,and was healed after active and effective therapy. The findings in this report suggest that early diagnosis and treatment are of significance for allopurinol-induced DRESS. Detection of HLA-B* 5801 plays a pivotal role in the diagnosis of allopurinol-induced DRESS.更多还原