【摘要】 目的探讨脑梗死患者踝肱指数(ABI)与颅内外血管狭窄的关系。方法选择新乡医学院第三附属医院2011年6月至2012年7月收治的脑梗死患者180例作为研究对象。根据颈动脉狭窄程度将患者分为无狭窄组(n=8)、轻度狭窄组(n=30)、中度狭窄组(n=85)和重度狭窄组(n=57);根据颅内动脉狭窄程度将患者分为无狭窄组(n=20)、轻度狭窄组(n=96)、中度狭窄组(n=49)、重度狭窄组(n=15)。比较各组患者的ABI、颈部血管内中膜厚度(IMT)、超敏C-反应蛋白(hs-CRP)和低密度脂蛋白胆固醇(LDL-C)水平,并分析ABI与IMT、hs-CRP及LDL-C之间的相关性。结果根据颈动脉狭窄程度进行分组时,轻度狭窄组、中度狭窄组、重度狭窄组患者ABI均低于无狭窄组,IMT均高于无狭窄组(P<0.05);轻度狭窄组、中度狭窄组、重度狭窄组患者ABI、IMT组间两两比较差异均有统计学意义(P<0.05);ABI与IMT呈负相关(r=-0.238,P<0.05)。根据颅内动脉狭窄程度进行分组时,轻度狭窄组、中度狭窄组、重度狭窄组患者ABI均低于无狭窄组,hs-CRP均高于无狭窄组,差异有统计学意义(P<0.05);轻度狭窄组、中度狭窄组、重度狭窄组患者ABI、hs-CRP组间两两比较差异均有统计学意义(P<0.05);各组患者间LDL-C比较差异均无统计学意义(P>0.05);ABI与hs-CRP、LDL-C呈负相关(r=-0.549、-0.124,P<0.05)。结论 ABI对脑梗死患者颅内外血管狭窄有预测价值。更多还原

【Abstract】 Objective To study the relation between ankle-brachial index( ABI) and arterial stenosis in patients with cerebral infarction. Methods One hundred and eighty patients with cerebral infarction in the Third Affiliated Hospital of Xinxiang Medical University from June 2011 to July 2012 were selected as study subjects. The patients were divided into no stenosis group( n = 8),mild stenosis group( n = 30),moderate stenosis group( n = 85) and severe stenosis group( n = 57) according to the degree of carotid artery stenosis; the patients were divided into no stenosis group( n = 20),mild stenosis group( n = 96),moderate stenosis group( n = 49) and severe stenosis group( n = 15) according to the degree of intracranial artery stenosis. The ABI,intima-media thickness( IMT),the levels of serum hypersensitive C reactive protein( hs-CRP) and low density lipoproteincholesterol( LDL-C) of patients were compared among the four groups and the correlation of ABI with IMT,hs-CRP,LDL-C was analyzed. Results The ABI of patients in mild stenosis group,moderate stenosis group and severe stenosis group was significantly lower than that in no stenosis group( P < 0. 05); the IMT,level of serum hs-CRP of patients in mild stenosis group,moderate stenosis group and severe stenosis group were significantly higher than those in no stenosis group( P < 0. 05). There was statistic difference in ABI,IMT and level of serum hs-CRP of patients among the mild stenosis group,moderate stenosis group and severe stenosis group( P < 0. 05). There was no statistic difference in the level of serum LDL-C of patients in each group( P > 0. 05).ABI was negatively correlated with IMT,hs-CRP and LDL-C( r =-0. 238,-0. 549,-0. 124; P < 0. 05). Conclusion ABI has predictive value on arterial stenosis in patients with cerebral infarction.更多还原