【摘要】 目的观察服用丙戊酸钠后癫痫患儿红细胞参数、肾功能和肝功能的变化。方法收集2015年7月至2015年12月于新乡医学院第三附属医院服用丙戊酸钠且丙戊酸钠血药浓度>60 mg·L^-1的253例癫痫患儿的临床资料,按照丙戊酸钠血药浓度分为低浓度组(60⁷0 mg·L^-1,53例)、中浓度组(71¹00 mg·L^-1,151例)和高浓度组(101¹20 mg·L^-1,49例),比较3组患儿红细胞、肾功能和肝功能各参数之间的差异。结果低浓度组、中浓度组、高浓度组患儿红细胞和肾功能参数比较差异均无统计学意义（P>0.05）;高浓度组患儿丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）水平均显著高于低浓度组和中浓度组（P<0.05）,低浓度组和中浓度组患儿ALT和AST比较差异均无统计学意义（P>0.05）。结论使用丙戊酸钠的患儿均可出现肝功能异常,严密监测患儿肝功能和丙戊酸钠血药浓度可以提高用药效果,减轻患儿肝脏毒性。更多还原

【Abstract】 Objective To observe the changes of red blood cell parameters,renal function and liver function in children with epilepsy after taking valproate. Methods The clinical data of 253 patients with epilepsy who were given valproate and the serum concentration of valproate was more than 60 mg·L^-1were collected from July 2015 to December 2015 in the Third Affiliated Hospital of Xinxiang Medical University. The patients were divided into low concentration group( 60-70 mg·L^-1,n =53),middle concentration group( 71-100 mg·L^-1,n = 151) and high concentration group( 101-120 mg·L^-1,n = 49) according to the serum concentration of valproate. The difference of red blood cell,renal function and liver function of patients were compared among the three groups. Results There was no significant difference in red blood cell and each index of renal function of patients among the low concentration group,middle concentration group and high concentration group（ P > 0. 05）.The alanine aminotransferase（ ALT） and aspartate aminotransferase（ AST） levels of patients in the high concentration group was significantly higher than that in the low concentration group and middle concentration group（ P < 0. 05）; there was no statistic difference in the ALT and AST levels between the low concentration group and middle concentration group（ P > 0. 05）.Conclusion Liver function abnormal can be observed in children who take valproate. Monitoring of the liver function and the serum concentration of valproate can improve the therapeutic effect and reduce the liver toxicity.更多还原