【摘要】 目的:分析吸烟、同型半胱氨酸(Hcy)、半胱氨酸蛋白酶抑制剂C(Cys C)、C反应蛋白(CRP)与年轻人冠心病(CHD)发病的关系。方法:选择我院收治因胸痛行选择性冠状动脉造影患者152例为研究对象,年龄均在45岁以下,依照检查结果分为CHD组(100例)和非CHD(52例),分析各组临床资料,并采用Logistic多元回归分析年轻CHD的独立危险因素。结果:与非冠心病组比较,冠心病组患者男性(30.8%比65.0%)、吸烟(46.1%比68.0%)、高血压(34.6%比51.0%)比例显著升高(P<0.05或<0.01),CysC[(0.85±0.16)mg/L比(1.34±0.28)mg/L]、CRP[(1.26±0.85)mg/L比(6.93±0.85)mg/L]、Hcy[(7.16±1.16)μmol/L比(20.85±2.16)μmol/L]、水平显著升高(P均<0.01);多元Logistic回归分析显示,男性,高血压,吸烟,Hcy和CRP是青年人发生冠心病的危险因素(OR=1.34~3.42,P<0.05或<0.01)。结论:男性,吸烟,同型半胱氨酸、Cys C及C反应蛋白是青年人发生冠心病的危险因素,应消除或降低这些危险因素的危险性。更多还原

【Abstract】 Objective:To analyze the relationship among smoking,levels of homocysteine(Hcy),cystatin C(CysC),C reactive protein(CRP)and coronary heart disease(CHD)onset in young people.Methods:A total of 152 patients,who received selective coronary angiography because of chest pain in our hospital,were enrolled,and all subjects were<45years old.According to examination results,they were divided into CHD group(n=100)and nonCHD group(n=52).Clinical data were analyzed in both groups,and Logistic multi-factor regression analysis was used to analyze independent risk factors for CHD in young people.Results:Compared with non-CHD group,there were significant rise in percentages of men(30.8% vs.65.0%),smoking(46.1% vs.68.0%)and hypertension(34.6% vs.51.0%),levels of CysC [(0.85±0.16)mg/L vs.(1.34±0.28)mg/L],CRP[(1.26±0.85)mg/L vs.(6.93±0.85)mg/L]and Hcy [(7.16±1.16)mol/L vs.(20.85±2.16)mol/L],P<0.05or<0.01;multi-factor Logistic regression analysis indicated that male,hypertension,smoking,Hcy,CysC and CRP were risk factors for CHD in young people(OR=1.34~3.42,P<0.05or<0.01).Conclusion:Male,smoking,total cholesterol,homocysteine,Cys C and C reactive protein are risk factors for CHD in young people.Therefore,these risk factors should be eliminated,or its risk should be reduced.更多还原