【摘要】 目的探讨小儿难治性支原体肺炎采用甲强龙冲击疗法治疗的临床效果。方法对2015年1月—2016年1月该院收治的104例小儿难治性支原体肺炎患儿的一般资料进行回顾性分析,所有患儿均经临床检查,确诊为小儿难治性支原体肺炎,患儿及家属均知情同意。按照随机数字表法,将104例小儿难治性支原体肺炎患儿按照随机数字表法分为实验组(甲强龙冲击疗法)与对照组(常规治疗)。对比两组治疗效果及退热时间、胸片恢复时间、肺部啰音消失时间、咳嗽减轻时间、白细胞计数、淋巴细胞计数等。结果实验组、对照组患儿临床有效率分别为90.4%(47/52)、71.2%(37/52),差异有统计学意义(P<0.05);实验组患儿退热时间、胸片恢复时间、肺部啰音消失时间、咳嗽减轻时间分别为(0.8±0.2)、(7.2±1.8)、(6.0±2.2)、(5.3±1.6)d,均短于对照组的(3.5±1.1)、(14.6±5.0)、(8.4±1.6)、(7.7±2.3)d,差异有统计学意义(P<0.05);实验组白细胞计数、淋巴细胞计数分别为(3.1±1.5)、(1.0±0.4)×103/μL,均优于对照组的(4.2±2.0)×103/μL、(1.4±0.7)×103/μL,差异有统计学意义(P<0.05)。结论在小儿难治性支原体肺炎患儿的临床治疗过程中,采用甲强龙冲击疗法的效果显著,能缩短患儿临床症状体征改善时间,控制白细胞及淋巴细胞计数,安全可靠,值得推广应用。更多还原

【Abstract】 Objective To discuss the clinical effect of methylprednisolone pulse therapy in treatment of refractory mycoplasma pneumoniae in children. Methods 104 cases of children with refractory mycoplasma pneumoniae admitted and treated in our hospital from January 2015 to January 2016 were selected and all patients were examined in clinic and diagnosed with refractory mycoplasma pneumoniae pneumonia after the informed content of the children and their family. 104 cases of children with refractory mycoplasma pneumoniae pneumonia were randomly divided into the experimental group(methylprednisolone pulse therapy) and the control group(routine treatment), and the treatment effect, and the treatment effect, defervescence time, sternum recovery time, lung rale disappearance time and cough relief time were compared between the two groups. Results The explerimentey group and contrd group with clinical effectiveness were 90.4%(47/52),71.2%(37/52).the difference was statistically siynificant(P<0.05).The defervescence time, sternum recovery time, lung rale disappearance time and cough relief time were respectively(0.8±0.2),(7.2±1.8),(6.0±2.2),(5.3±1.6)d, which were shorter than those in the control group(3.5±1.1),(14.6±5.0),(18.4±1.6)d, and the differences had statistical significance(P<0.05), and the white cell count and lymphocyte count in the experimental group were better than those in the control group,[(3.1±1.5)×103/μL,(1.0±0.4)×103/μL vs(4.2±2.0)×103/μL,(1.4±0.7)×103/μL], and the differences had statistical significance(P<0.05). Conclusion The effect of methylprednisolone pulse therapy in treatment of refractory mycoplasma pneumoniae in children is obvious, which can shorten the clinical symptom improvement time and control the white cell count and lymphocyte count, and it is safe and reliable, which is worth promotion and application.更多还原