【摘要】 目的研究紧张型头痛(TTH)患者血清白细胞介素-8(IL-8)水平变化及临床意义。方法筛选TTH患者60例(TTH组),给予天舒胶囊治疗8 w,采用ELISA法检测治疗前后外周血IL-8和5-羟色胺(5-HT)的水平及疼痛视觉模拟评分(VAS),并与60例健康者(对照组)进行对照分析。结果治疗前,TTH组血清IL-8水平和VAS评分均明显高于对照组(P<0.01),而血清5-HT水平明显低于对照组(P<0.01)。与治疗前相比,治疗后TTH组血清IL-8水平和VAS评分均明显减低(P<0.01),而5-HT水平明显升高(P<0.01)。TTH组血清5-HT水平与疼痛VAS评分呈显著负相关(r=-0.736,P<0.01),而IL-8水平与疼痛VAS评分呈正相关(r=0.742,P<0.01)。结论 TTH患者血清IL-8和5-HT水平与疼痛程度有相关性,或许可作为TTH严重程度的间接评估指标。更多还原

【Abstract】 Objective To study the changes in the serum interleukin 8(IL-8) levels in patients with tension-type headache(TTH)and its clinical significance. Methods 60 patients with TTH were selected and treated with Tianshu Capsule for eight weeks(TTH group); the levels of peripheral blood(PB) IL-8 and 5-hydroxytryptamine(5-HT) and the visual analogue scale(VAS) scores before and after the treatment were detected by use of ELISA method. A contrast analysis was conducted on the results and those in the control group(constituted by 60 healthy persons). Results Before the treatment, the serum IL-8 levels and VAS scores were significantly higher than those in the control group(P < 0.01), while the serum 5-HT levels was much lower than that in the control group(P <0.01). Compared wi th those before the treatment, the post-treatment serum IL-8 levels and VAS scores in TTH group decreased significantly(P < 0.01), while the serum 5-HT levels increased significantly(P < 0.01). The serum 5-HT levels were in significant negative correlation with VAS scores in TTH group(r=-0.736, P < 0.01), while IL-8 levels were in positive correlation with VAS scores(r =0.742, P < 0.01). Conclusion The serum IL-8 and 5-HT levels in patients with TTH are correlated with the pain degree, which may be used as an indirect index for evaluating the severity of TTH.更多还原