【摘要】 目的探讨阻塞性睡眠呼吸暂停低通气综合症(OSAHS)患者血清长正五聚蛋白3(PTX3)和低氧诱导因子(HIF)-1α水平的变化及与OSAHS的关系。方法根据睡眠呼吸暂停低通气指数(AHI)将90例男性OSAHS患者分为轻度组(21例)、中度组(36例)与重度组(33例),并入选同期30例男性健康者作为对照组。采用ELISA法测定各组血清PTX3和HIF-1α水平,采用Pearson法对PTX3和HIF-1α水平与OSAHS疾病程度的关系进行相关性分析。结果 4组PTX3和HIF-1α比较,均有显著差异(P<0.01),从低到高依次为对照组、轻度组、中度组与重度组。相关性分析显示,血清PTX3水平和HIF-1α变化与OSAHS疾病程度变化呈正相关(r=0.966、0.961,P<0.01)。结论血清PTX3和HIF-1α水平与OSAHS患者疾病程度呈正相关,检测这两项指标有助于判断OSAHS疾病程度。更多还原

【Abstract】 Objective To explore the relation of the changes in the levels of serum long pentraxin 3(PTX3) and hypoxiainducible factor(HIF)-1α with obstructive sleep apnea-hypopnea syndrome(OSAHS) in the patients with OSAHS. Methods A total of90 male patients with OSAHS were divided into a minor group(n=21), a moderate group(n=36) and a severe group(n=33) according to the apnea-hypopnea indexes(AHI), and another 30 male healthy persons were selected to constitute a control group. ELISA method was used for determining the levels of serum PTX3 and HIF-1α in each group and Pearson method applied to conducting correlation analysis on the relation of PTX3 and HIF-1α levels with the degree of OSAHS. Results There was significant difference in the PTX3 and HIF-1α among the four groups(P < 0.01), and the order from low to high was: the control group, the minor group, the moderate group and the severe group. Correlation analysis showed that the changes in the levels of serum PTX3 and HIF-1α were positively correlated with the degree of OSAHS(r=0.966, 0.961, P < 0.01). Conclusion The levels of serum PTX3 and HIF-1α are positively correlated with the degree of OSAHS. Therefore, the determination of the two indexes is helpful for the judgment of the degree of OSAHS.更多还原