【摘要】 刺激前负波(Stimulus-Preceding Negativity,SPN)是从关联性负变化中分离出来的非运动性慢电位,其波幅随着反馈刺激的临近逐渐升高。先前研究侧重于将SPN视为一种认知性成分,而最近的研究支持了SPN是奖赏期待的可靠指标。本文从奖赏的基本属性、结果评价、神经发生源以及特殊人群等角度,对SPN反映奖赏期待这一假说进行了梳理,并提出了未来的研究方向,旨在为研究奖赏期待受损的神经精神类疾病提供可靠的生物学标记。更多还原

【Abstract】 As a nonmotoric slow potential isolated from the contingent negative variation, the stimuluspreceding negativity(SPN) progressively increases as feedback stimuli approach. Previous studies have mainly regarded the SPN as a cognitive component. However, recent evidence points to the hypothesis that the SPN may constitute an electrophysiological index of reward anticipation. Here, we justified this hypothesis in terms of reward parameters, outcome appraisal, neutral generators, and abnormal individuals, and provided some suggestions for future SPN research. We believed that the SPN provides a reliable biological marker of abnormal reward anticipation in neurological and psychiatric disorders.更多还原