【摘要】 目的探讨新疆巴楚县维吾尔族妇女宫颈病变检出率和HPV感染率与当地土壤中微量元素的相关性,为新疆维吾尔族宫颈癌的防治提供基础。方法 2014年3月1日-6月15日随机选择巴楚县9个乡镇,每个乡镇选取农田土壤42处,包括红枣、小麦和玉米地,采集的土壤样品采用原子吸收发光法对Cu、Zn、Fe、Ni、Se进行检测,土壤中微量元素水平与维吾尔族妇女宫颈病变检出率和HPV感染率相关性采用偏相关分析。结果新疆喀什地区巴楚县维吾尔族妇女HPV感染阳性率为9.3%,宫颈高级别病变及宫颈癌的检出率为1.33%。土壤中Ni、Cu、Zn、Se和Fe微量元素水平的均值均未超过中华人民共和国国家环境土壤标准。土壤中Cu水平与宫颈高级别病变及宫颈癌检出率呈正相关(rs=0.498,P=0.019),Se水平与维吾尔族妇女宫颈病变检出率呈负相关(rs=-0.461,P=0.041),土壤中Se水平与维吾尔族妇女HPV感染率呈负相关(rs=-0.522,P=0.040)。结论土壤中缺硒、富铜可能与新疆巴楚县维吾尔族妇女宫颈高级别病变、宫颈癌与HPV感染有关。更多还原

【Abstract】 Objective To analyze the relationship between HPV infection,CIN2 + and soil mineral elements in Bachu county,Kashi,Xinjiang to provide information for the cervical cancer prevention in Xinjiang. Methods 42 soil specimen of 9 towns of Bachu county were randomly selected from red date field,wheat field and corn field in every town,and Ni,Cu,Zn,Se,Fe were tested by atomic absorption spectrometry method. Partial correlative analyses was used for statistical analysis. Results HPV infection rate was 9. 3% among Bachu Uyghur women,CIN2+ detection rate was 1. 33%. Average value of Ni,Cu,Zn,Se,Fe were up to the national standard. Cu in the soil showed positive correlation with CIN2 +( rs= 0. 498,P = 0. 019),while Se showed negative correlation( rs=- 0. 461,P = 0. 041). Se also negatively correlated with HPV infection( rs=- 0. 522,P = 0. 040). Conclusion Excess of Cu and poor of Se in soil maybe were correlated with Uyghur HPV infection and high grade cervical lesion and cervical cancer in Bachu of Xinjiang.更多还原