【摘要】 目的探讨"通督治郁"针灸疗法对脑卒中后抑郁症(PSD)患者临床疗效及对血清5-羟色胺(5-HT)、去甲肾上腺素(NE)和脑源性神经营养因子(BDNF)水平的影响。方法通过对本院2014年5月~2016年4月住院部和门诊治疗的120例PSD患者临床资料做回顾性分析,并根据治疗方式的不同分为A组、B组、C组3组,(采用"通督治郁"针灸疗法治疗为A组、采取常规针刺治疗为B组、采取西药治疗为C组)各40例。比较并分析3组患者血清5-HT、NE和BDNF表达水平及治疗前后的治疗疗效。结果 3组患者经各自方案治疗后,HAMD评分均较治疗前改善,差异具有统计学意义(P<0.05),且治疗后A组HAMD评分明显低于B组和C组,差异具有统计学意义(P<0.05),但治疗后B组和C组HAMD评分比较差异无统计学意义(P>0.05)。3组患者治疗前NE、5-HT、BDNF水平含量比较差异均无统计学意义(P>0.05),经治疗后三组患者NE、5-HT、BDNF水平含量均较治疗前上升(P<0.05),且治疗后A组NE、5-HT、BDNF水平含量均明显高于B组、C组(P<0.05),但B组和C组NE、5-HT、BDNF水平含量比较差异无统计学意义(P>0.05)。3组患者经各自方案治疗后A组抑郁症状改善总有效率(90.00%)明显高于B组(65.00%)、C组(60.00%),差异具有统计学意义(P<0.05),但B组和C组总有效率比较(65.00%/60.00%),差异无统计学意义(P>0.05)。结论 "通督治郁"针灸疗法在可显效地改善PSD患者抑郁症状,且可明显地提高PSD患者血清中的NE、5-HT、BDNF的表达水平。更多还原

【Abstract】 Objective To investigate the clinical effect of " Tong Du Zhi Yu" acupuncture and moxibustion therapy on post-stroke depression(PSD)patients and their effects on serotonin(5-HT),norepinephrine(NE)and brain-derived nerve(BDNF)levels.Methods The clinical data of 120 patients with PSD were retrospectively analyzed.The patients were divided into group A,B and C according to the different treatment methods.The group A was treated with acupuncture and moxibustion.The group B was treated with routine acupuncture.The group C was treated with western medicine.The levels of serum 5-HT,NE and BDNF were compared before and after the treatment.Results HAMD scores of the three groups were improved after treatment(P<0.05).HAMD score of group A was significantly lower than that of group B and group C after treatment(P<0.05).No significant difference was detected in HAMD score between group B and group C after treatment(P>0.05).The total effective rate of group A(90.00%)was significantly higher than that of group B(65.00%)and group C(60.00%)(P<0.05).No significant difference was detected in the total effective rate between group B and group C(65.00%/60.00%)(P>0.05).No significant differences was detected in NE,5-HT and BDEF levels among the three groups before treatment(P>0.05).The levels of NE,5-HT and BDEF in the three groups after treatment were higher than those before treatment(P<0.05).The levels of NE,5-HT and BDEF in group A were significantly higher than those in group B and C(P<0.05).No significant differences were detected in NE,5-HT and BDEF levels between group B and group C(P>0.05).Conclusion " Tong Du Zhi Yu" acupuncture therapy can significantly improve depressive symptoms in PSD patients,and significantly improve the serum levels of NE,5-HT and BDEF in PSD patients.更多还原