【摘要】 目的探讨职业紧张和多囊卵巢综合征发病风险的相关关系。方法从四川大学华西妇女儿童医院生殖内分泌科门诊共纳入初次诊断为多囊卵巢的260例病人和243例对照。采用职业紧张量表(OSI-R)调查多囊卵巢的职业紧张水平。采用多因素Logistic回归分析职业紧张和其他环境因素对多囊卵巢发病风险的影响程度,采用Pearson相关分析职业紧张与HOMA-IR的相关关系。结果 Logistic回归分析发现,职业任务过重(OR=1.11,95%CI=1.04~1.17)和个人紧张反应较高(OR=1.30,95%CI=1.19~1.41)均能增加职业紧张的发病风险;较高的应对资源能力(OR=0.89,95%CI=0.83~0.95)能降低多囊卵巢的发病风险。饮酒(OR=27.58,95%CI=5.83~130.62)、有家族性秃头史(OR=23.60,95%CI=2.52~221.11)、较高的HOMA-IR(OR=15.21,95%CI=6.56~35.27)、BMI(OR=1.50,95%CI=1.21~1.86)、体重(OR=1.13,95%CI=1.01~1.26)和较长的工作年限(OR=1.44,95%CI=1.05~1.98)能增加多囊卵巢的发病风险。然而,经常的体育锻炼能够降低多囊卵巢的发病风险(OR=0.18,95%CI=0.04~0.77)。职业紧张3个维度与HOMA-IR均有相关关系。结论职业紧张与多囊卵巢发病风险有关,并且职业紧张与胰岛素抵抗水平有相关关系。更多还原

【Abstract】 Objective We aimed to investigate the association between occupational stress and polycystic ovary syndrome(PCOS). Methods By case-control design, a total of 260 patients with PCOS and 243 controls were recruited from the Department of Reproductive Endocrinology in West China Second University Hospital/West China Women’s and Children’s Hospital between March 2016 and June 2016. The OSI-R questionnaire was used for investigation. The data of fasting serum glucose and insulin were collected from medical records. The multiple logistic regression analysis was conducted to analyze the correlation between occupational stress and PCOS. Correlation analysis was conducted to estimate the correlation between occupational stress and HOMA-IR. Results Multiple logistic regression analysis showed that occupational role(ORQ), personal strain(PSQ) and personal resources(PRQ)( OR =1.30, 95% CI =1.19-1.41) were associated with PCOS. Moreover, more years of employment(OR=0.89, 95% CI=0.83-0.95), higher BMI(OR=13.157, 95% CI=5.176-33.446), higher weight(OR=1.13, 95% CI=1.01-1.26), higher HOMA-IR, and a habit of alcohol drinking(OR=1.14, 95% CI =1.051-1.236) and alopecia were significantly associated with PCOS. Correlation analysis indicated a significant association between three dimensions of occupational stress and HOMA-IR. Conclusion We observed that occupational stress was significantly associated with PCOS, and also associated with HOMA-IR.更多还原