【摘要】 目的探讨胃癌的环境危险因素及其人群归因危险度。方法通过病例-对照研究,收集福建省仙游县医院经组织病理学确诊的新发胃癌共335例;同期按年龄、性别进行匹配,选取医院其他科室病人和健康人群作为对照。通过问卷调查获取病例及对照的饮食、饮食习惯等信息。应用条件Logistic回归进行胃癌环境危险因素的单因素和多因素分析并计算人群归因危险度。结果多因素条件Logistic回归分析结果:最早使用农药年龄≤18岁,饮食较烫,经常食用腌菜,经常辛辣饮食,高盐饮食为环境危险因素,人群归因危险度分别为38.95%、26.92%、25.38%、22.70%、21.59%,综合归因危险度为84.82%。结论使用农药、经常食用腌菜及不良饮食习惯(较烫、辛辣饮食及高盐饮食)是仙游县胃癌发生主要影响因素,指导仙游县居民正确喷洒农药、健康的饮食习惯对防控胃癌有重要意义。更多还原

【Abstract】 Objective The aim of this study was to investigate the environmental risk factors of gastric cancer and population attributable risks. Methods Case-control study was conducted among 335 patients and 961 control subjects. Patients were recruited from the Xianyou county hospital with histological confirmation. Hospital control subjects were collected from Xianyou county hospital and were matched to the cases on gender and age. Healthy control subjects were collected in same villages. Eligible subjects were personally interviewed using a questionnaire and general information was collected, including diet habit,habits and customs and so on. Univariate and multivariate conditional logistic regression were used to identify the risk factors of gastric cancer and their population attributable risks. Results Multivariate conditional logistic regression results showed that using pesticides age≤ 18, eating hot food, often intake pickles, eating spicy food, taste(salt), and the adjusted factors in population attributable risk were 38.95%, 26.92%, 25.38%, 22.70%, 21.59%, and the s PAR rate was 84.82%.Conclusion Using pesticides, often intake pickles and bad eating habits(eating hot food, eating spicy food, taste(salt)) were the main influencing factors on gastric cancer. Guiding the residents of Xianyoucounty in the correct spraying of pesticides and healthy eating habits were important for the prevention and control of gastric cancer.更多还原