【摘要】 背景:临床研究证实了低频脉冲电磁场除了用于骨折延迟愈合与骨不连外,对新鲜骨折、骨切除术及疲劳骨折的治疗也有显著疗效。目的:系统评价低频脉冲电磁场促进骨愈合的临床疗效和安全性。方法:通过检索中国学术期刊全文数据库(CNKI)、美国国立医学图书馆生物医学信息检索系统(Pub Med)等数据库中1985年1月至2016年5月有关低频脉冲电磁场促进骨折愈合的随机对照临床研究文献,对纳入文献进行资料提取、方法学质量评价,并采用Rev Man5.1软件进行统计分析。结果与结论:(1)有13篇文献符合纳入标准,共有1 244例患者,均为随机对照临床试验;(2)Meta分析结果显示:低频脉冲电磁场治疗组的总体有效率高于对照组的总体有效率;治疗组的骨折愈合时间显著低于对照组的骨折愈合时间;治疗组的骨密度显著高于对照组的骨密度;(3)结果说明,低频脉冲电磁场促进骨折愈合的总有效率较高,能显著缩短骨折愈合时间且安全性较高,但还需要大量Jadad法评分高的多中心、大样本量随机对照临床试验来进一步验证。更多还原

【Abstract】 BACKGROUND: Low frequency-pulsed electromagnetic fields(LF-PEMFs) have been confirmed to not only treat delayed bone union or nonunion, but also be effective for fresh bone fractures, ostectomy and fatigue fractures. OBJECTIVE: To systematically evaluate the efficacy and safety of LF-PEMFs for bone healing.METHODS: CNKI and Pub Med databases were retrieved for the randomized controlled trials concerning LF-PEMFs promoting bone healing published from January 1985 to May 2016. Meta-analysis was conducted on Rev Man 5.1 software after data management and quality assessment. RESULTS AND CONCLUSION: Thirteen eligible literatures were enrolled, involving 1244 patients. Meta-analysis showed that the overall effectiveness and bone mineral density in the LF-PEMFs group were significantly higher than those in the control group. The healing time in the LF-PEMFs group was significantly shorter than that in the control group. These results suggest that LF-PEMFs show high efficacy and safety for bone healing, and also can markedly shorten the healing time. However, more high-quality multi-center, large-scale randomized controlled trials are still needed to testify all above conclusions.更多还原