【摘要】 背景:骨关节炎作为退行性关节疾病,软骨损伤和组织缺失不能完全解释其发病机制,骨重建的失衡以及关节内组织相互作用可能在疾病过程中有重要意义。目的:对骨-软骨交互作用在骨关节炎的发生发展过程中产生的作用及新的治疗策略进行综述。方法:由第一作者检索2007至2017年Pub Med及中国知网等数据库收录的关于骨关节炎的发生发展与骨-软骨交互作用关系的实验研究及研究进展的文献。中文检索词分别为"骨、软骨、交互作用、骨关节炎、发病机制、细胞因子、信号通路",英文检索词分别为"cartilage;interaction;osteoarthritis;pathogenesis;cytokines;signaling pathway",文章从细胞因子、信号通路、新型治疗策略3个方面,对骨-软骨交互作用与骨关节炎发生发展的关系进行综述。结果与结论:共检索到169篇文章,按纳入和排除标准对文献进行筛选,共纳入54篇文章。软骨同软骨下骨的解剖结构联系密切,骨与软骨构成了一个功能协同的整体单元。在骨关节炎发生发展过程中,骨重建异常以及新生血管数量的增加、微裂缝的形成,促进了分子信号在骨-软骨间的转位和交互作用。骨-软骨的交互作用是骨关节炎发生发展的病理中心。更多还原

【Abstract】 BACKGROUND:Osteoarthritis,a degenerative joint disease,is not only a result from the breakdown of joint cartilage and underlying bone,but also an imbalance of bone remodeling and crosstalk among tissues in the joints.OBJECTIVE:To review the effect of bone-cartilage crosstalk in the progression of osteoarthritis and its new treatment strategy.METHODS:A computer-based search of Pub Med and CNKI databases was performed for relevant literatures about the relationship between the progress of osteoarthritis and the bone-cartilage crosstalk published from 2007 to 2017.The keywords were "cartilage,interaction,osteoarthritis,pathogenesis,cytokines,signaling pathway" in English and Chinese,respectively.The relationship between the progress of osteoarthritis and the bone-cartilage crosstalk was summarized in views of cytokines,signaling pathway,and new treatment strategy.RESULTS AND CONCLUSION:Totally 169 articles were retrieved,and finally 54 eligible papers were enrolled based on the inclusion and exclusion criteria.There is a close physical association between subchondral bone and cartilage,and the bone-cartilage interface is a functioning synergistic unit.Increased vascularization,micro-crack formation and abnormal bone remodeling may accelerate the molecules transporting from cartilage to bone in osteoarthritis.Therefore,the bone-cartilage crosstalk plays a pivotal role in the occurrence and development of osteoarthritis.更多还原